How aggravated doshas produce disease

Aggravated doshas spread singly, in pairs, all three together, or with blood, fifteen patterns in all, lodge in a site where the channels are faulty and cause the diseases of that site (in the abdomen gulma, diarrhoea or weak digestion; in the bladder prameha, dysuria or stone), which then become manifest and differentiated. The best physician knows these six stages and treats early, when it is easiest; health is protected by calming accumulated doshas and removing aggravated ones by emesis and similar means.